Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
نویسندگان
چکیده
منابع مشابه
Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
Spatial patterns of brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD) were measured via methods of computational neuroanatomy. These patterns were spatially complex and involved many brain regions. In addition to the hippocampus and the medial temporal lobe gray matter, a number of other regions displayed significant atrophy, including orbitofrontal and medial-prefro...
متن کاملTitle: Caudate Atrophy & Clinical Correlates in 400 Alzheimer’s Disease, MCI, & Healthy Elderly Subjects Authors:
Introduction: Alzheimer’s disease (AD) affects 35 million people worldwide (Dartigues, 2009). AD research using MRI has focused on early changes in medial temporal and cortical gray matter. Although caudate atrophy is more typical of motor disorders such as Parkinson’s disease (Nakamura et al. 2001), beta-amyloid and tau pathology accumulates in the caudate in AD (Braak and Braak, 1990). Here w...
متن کاملAmnestic MCI or prodromal Alzheimer's disease?
The concept of mild cognitive impairment (MCI) draws attention to cognitive changes not severe enough to warrant the diagnosis of dementia. As used today, it covers many pathological disorders and characterises a diverse population of patients who attend memory clinics. Our concern is the underlying heterogeneity. We suggest that it will soon be possible (if it is not already) to identify the u...
متن کاملThe Value of Hippocampal and Temporal Horn Volumes and Rates of Change in Predicting Future Conversion to AD
Hippocampal pathology occurs early in Alzheimer disease (AD), and atrophy, measured by volumes and volume changes, may predict which subjects will develop AD. Measures of the temporal horn (TH), which is situated adjacent to the hippocampus, may also indicate early changes in AD. Previous studies suggest that these metrics can predict conversion from amnestic mild cognitive impairment (MCI) to ...
متن کاملSurgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment.
BACKGROUND Structural magnetic resonance imaging is used to longitudinally monitor the progression of Alzheimer disease from its presymptomatic to symptomatic phases. Using magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative, we tested the hypothesis that surgery would impact brain parameters associated with progression of dementia. METHODS Brain images from t...
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ژورنال
عنوان ژورنال: Neurology
سال: 2005
ISSN: 0028-3878,1526-632X
DOI: 10.1212/01.wnl.0000180958.22678.91